The antioxidant effects of CoQ10 are well-established. A number of studies have shown that CoQ10 reduces the initiation and propagation of lipid peroxidation in cell membranes and in lipoprotein fractions.

In heart disease, CoQ10 has shown benefits in patiennts with heart failure - 50mg daily for 4 weeks resulted in improvements in dyspnea, heart rate, blood pressure, and ankle edema. cardiac patients supplemented with CoQ10 prior to heart surgery tend to recover sooner and maintain blood and tissue levels of CoQ10 better than patients not receiving supplements. Finally, individuals taking cholesterol-lowering medications (HMG-CoA reductase inhibitors such as pravastatin) may benefit from CoQ10 supplements because these medications can reduce blood levels of CoQ10.